There have been clashes between Palestinians and Israeli police outside the Al-Aqsa mosque in Jerusalem, ahead of a planned Jewish nationalist march.
More than 300 people were injured, as crowds threw stones and officers fired stun grenades and rubber bullets.
It comes amid soaring tensions in the city, which has seen weeks of unrest.
Earlier, Israeli police decided to bar Jews from visiting the compound where the mosque is located during the annual Jerusalem Day Flag March.
The event marks Israel's capture of East Jerusalem - home to the Old City and its holy sites - in 1967, and usually sees hundreds of flag-waving Israeli youth make their way through Muslim areas via Damascus Gate, chanting and singing patriotic songs.
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It is regarded by many Palestinians as a deliberate provocation. This year's march is also taking place in the final days of the Islamic holy month of Ramadan.
The al-Aqsa mosque, the third holiest site in Islam, is located on a hilltop complex known by Muslims as the Haram al-Sharif (Noble Sanctuary) and by Jews as the Temple Mount. Jews revere it as the location of two Biblical Temples and it is the holiest site in Judaism.
What makes Jerusalem so holy?
The Israel-Palestinian conflict explained
The latest violence follows days of clashes between Palestinians and Israeli police in the nearby Sheikh Jarrah district of East Jerusalem, with the possible eviction of Palestinian families from their homes there by Jewish settlers a focal point for Palestinian anger.
Israel's Supreme Court had been due to hold a hearing in the long-running case on Monday, but the session was postponed due to the unrest.Fears had mounted that it would be a tense day in Jerusalem and so it turned out. The confrontation started first thing in the morning.
As I passed the Old City walls beneath the glittering Dome of the Rock, heavily armed Israeli police had entered the compound and were firing volleys of stun grenades at Palestinians who were throwing stones and other objects at them. Ambulances screamed past ready to ferry away the wounded.
The site holy to Muslims and Jews lies at the core of the region's conflict.
Hundreds of Jewish activists had planned to go there in the morning, but were ultimately stopped by police. Muslim worshippers had stayed in al-Aqsa all night - ready, they said, to defend their mosque.
The city's surging tensions stem from several causes. Among them, the threatened eviction of several Palestinians families from their homes in East Jerusalem by Jewish settlers.
That case is now on hold for several weeks after Israel's government intervened. But despite the growing international calls for calm, today has seen more fuel poured on an already volatile mix.What happened at the al-Aqsa mosque?
Israel's police force said thousands of Palestinians barricaded themselves in the building overnight with stones and Molotov cocktails in anticipation of a confrontation during the Jerusalem Day Flag March, which was scheduled to start at about 16:00 (13:00 GMT).The BBC is not responsible for the content of external sites.
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Officers were ordered to enter the mosque compound to "repel the rioters using demonstration dispersal methods" on Monday morning after a police post was attacked and stones were thrown towards a nearby road, it added.
For over an hour, police fired stun grenades, rubber bullets and tear gas at Palestinians, who threw stones and other objects.
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